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Pharmacogenomics (PGx), the study of how an individual’s genomic profile influences his or her response to drugs, has emerged as a clinical tool to optimize drug therapy. Certain genetic variants increase the risk of severe, life-threatening adverse effects from certain drugs. Meanwhile, other genetic traits are predictive of decreased response. Integrating pharmacogenomics into clinical practice to assist in drug selection and dosing has the potential to improve the outcomes of treatment, reduce the risk of drug-induced morbidity and death, and contribute to more cost-effective healthcare. The field of pharmacogenomics is developing rapidly and we are looking for an ambitious PhD candidate to pursue his/her research in contributing to the development of next-generation PGx methodologies.
The aim of this bioinformatics research project is to facilitate genomics medicine and include the genomic information layer in the clinical decision process. Hence, we aim to investigate and develop new approaches for utilizing genome data interactions between molecular intermediates, like, e.g., genome-proteome and genome-epigenome and drug-protein that are relevant for the clinical outcomes. These approaches will be evaluated and applied on clinal-grade whole-genome sequencing data generated at the Jessa Hospital.
We are looking for a highly motivated and scientifically excellent candidate in the genomics/bioinformatics background with a problem-solving attitude to work in an international, collegial environment. Strong communication skills complemented with innovative analytical thinking are important assets. This project is a strategical collaboration with VITO, Jessa Hospital Hasselt & University of Hasselt and the candidate will be a member of all institutions.
For more information, do not hesitate to contact Gökhan Ertaylan.
Please submit your application through the VITO application portal by uploading your motivation letter (max.1 page), short CV (max. 3 pages), a transcript from the MSc degree, and three names of referees.
After being selected as PhD candidate, you will prepare a formal PhD application and defend it for a VITO-jury. The next PhD jury will be organised on June 2nd, 2023 (registration deadline 29/03/2023).
You will work in a multidisciplinary environment under the supervision of senior scientists with experience in Clinical Pathology, Bioinformatics, Computational Biology and Data Science, and under the guidance of your university promoter from the University of Hasselt and Jessa Hospital Hasselt as well as VITO.